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Cotterill, J. Peony-glycyrrhiza decoction, an herbal preparation, inhibits clozapine metabolism via cytochrome P450s, but not flavin-containing monooxygenase in in vitro models. Dying for a cup of tea. Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Taking too much licorice can cause high blood pressure. Armanini D, Lewicka S, Pratesi C, et al. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. View abstract. Licorice is available in many different types of products, including candies, lozenges, teas, chewing, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Side effects in people after breathing tube removal. Lee YS, Lorenzo BJ, Koufis T, et al. CJEM 2010;12(3):224-225. Zhou, Y., Huang, Z., and Huang, T. [Clinical study of shengxue mixture in treating aplastic anemia]. Purnak, T., Ozaslan, E., Beyazit, Y., and Haznedaroglu, I. C. Upper gastrointestinal bleeding in a patient with defective hemostasis successfully treated with ankaferd blood stopper. J Clin Psychopharmacol 1997;17(3):234-235. Zhongguo Zhong Xi Yi Jie He Za Zhi. Xu Y, Li X, Chen T, et al. Licorice can decrease how quickly the body breaks down corticosteroids. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Am J Respir.Cell Mol.Biol. [Clinical observation on auxiliary treatment of hormone dependence dermatitis by shufeng liangxue decoction]. White Peony is technically named Peonia lactiflora, and in Chinese, it is named Bai Shao. Deng, Y. Y., Chen, Y. P., Wang, L., Hu, Z., Jin, Y., Shen, L., Zhu, R., and Zhong, Y. N Engl J Med 1968;278(25):1381-1383. View abstract. Medicine (Baltimore) 2018;97(11):e0073. Unfortunately, there is not much scientific evidence around the use of Licorice in Hirsutism, and more studies are needed to prove if it's effective in hirsutism or not. Lapi F, Gallo E, Bernasconi S, et al. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. Hsu, Y. L., Wu, L. Y., Hou, M. F., Tsai, E. M., Lee, J. N., Liang, H. L., Jong, Y. J., Hung, C. H., and Kuo, P. L. Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway. Licorice is believed to have anti-androgenic effects, meaning that it may be active to reduce testosterone levels. Assessment of the therapeutic effect of total glycosides of peony for juvenile idiopathic arthritis: a systematic review and meta-analysis. View abstract. It has an effect similar to aldosterone. BMJ 1997;314:731-2. Akamatsu, H., Komura, J., Asada, Y., and Niwa, Y. Nahidi F, Zare E, Mojab F, Alavi-Majd H. Effects of licorice on relief and recurrence of menopausal hot flashes. Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions. View abstract. N Engl J Med 1991;325:1223-7. View abstract. Br Med J 1971;3(773):501-503. J Clin Psychopharmacol 2016;36(6):572-9. Medicinal herbs: modulation of estrogen action. Complement Ther Med. Int J Environ Res Public Health 2021;19(1):242. Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats. Information from this source is evidence-based and objective, and without commercial influence. View abstract. typica. Izv Akad Nauk Ser Biol 1997;2:235-7. . Removes excess melanin: Licorice extract brightens the skin in another way, too. Some possible side effects with oral use include rash, itching, nasal symptoms, or stomach discomfort, but these are uncommon. Biol Pharm Bull 1998;21:1277-81. 2019;35:329-41. Cancer Lett. Crean, A. M., Abdel-Rahman, S. E., and Greenwood, J. P. A sweet tooth as the root cause of cardiac arrest. View abstract. Lee, C. K., Park, K. K., Lim, S. S., Park, J. H., and Chung, W. Y. Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents. View abstract. Cooper, H., Bhattacharya, B., Verma, V., McCulloch, A. J., Smellie, W. S., and Heald, A. H. Liquorice and soy sauce, a life-saving concoction in a patient with Addison's disease. Dehours E, Vall B, Roug-Bugat ME, Florent B, Bounes V, Franchitto N. Suspected hypokalaemia following liquorice ingestion on board ship. . Some medications are changed and broken down by the liver. Hum Exp Toxicol 2012;31(12):1295-1298. A., Keller, W. J., Pereira, M. A., and Kinghorn, A. D. Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). Hajiaghamohammadi, A. View abstract. Eagon PK, Elm MS, Hunter DS, et al. Am.J Chin Med 2004;32(4):569-578. View abstract. View abstract. Brasseur, A. and Ducobu, J. View abstract. Select a condition to view a list of vitamins. J Cardiovasc.Surg (Torino) 2000;41(4):631-632. Armanini D, De Palo CB, Mattarello MJ, et al. Cardiovasc.Drugs Ther 1998;12(6):599-600. People who regularly take large amounts of licorice, more than 20 g/day, may raise blood levels of the hormone aldosterone, which can cause serious side effects, including headache, high blood pressure, and heart problems. Taking peony along with birth control pills might increase the risk of side effects. Prospective study]. Mol Cell Endocrinol. Some birth control pills contain estrogen. View abstract. View abstract. A laboratory evaluation of the antibacterial and cytotoxic effect of Liquorice when used as root canal medicament. Phytother Res. West J Med 1997;167(3):184-185. Abe K, Higurashi T, Takahashi M, et al. Kang, D. G., Moon, M. K., Choi, D. H., Lee, J. K., Kwon, T. O., and Lee, H. S. Vasodilatory and anti-inflammatory effects of the 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) via a nitric oxide-cGMP pathway. View abstract. View abstract. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Mouthwash Containing Glycyrrhiza uralensis Extract for Preventing Dental Caries. Ito, M., Nakashima, H., Baba, M., Pauwels, R., De Clercq, E., Shigeta, S., and Yamamoto, N. Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV- III/LAV)]. A man in Massachusetts died after eating too much black licorice, which contains a compound known to be toxic in large doses, according to a new report. Be sure to have your blood checked regularly. Z. View abstract. View abstract. View abstract. 5-10-2004;208(1):89-94. Mol.Nutr Food Res 2011;55(2):318-327. Zhong Xi Yi Jie He Za Zhi 1990;10:101-2, 70. . Chin J Integr Med 2022. Taking peony along with medications that also slow blood clotting might increase the risk of bruising and bleeding. Previous studies have estimated that a dose of 1 to 5 grams (g) of licorice root daily is safe for most adults. View abstract. N Engl J Med. Blood Press. Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, Bensoussan A. Lee, S., Lim, J. M., Jin, M. H., Park, H. K., Lee, E. J., Kang, S., Kim, Y. S., and Cho, W. G. Partially purified paeoniflorin exerts protective effects on UV-induced DNA damage and reduces facial wrinkles in human skin. Phytother.Res 2004;18(3):241-243. A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. Peony-glycyrrhiza decoction for antipsychotic-related hyperprolactinemia in women with schizophrenia: a randomized controlled trial. BMJ Case Rep. 2013 Sep 19;2013. Moreover, it will be necessary to check for recurrence . J Ethnopharmacol 2004;94:339-44. . Clinical trial of deglydyrrhizinized liquorice in gastric ulcer. World J Gastroenterol 2005;11:2124-9. . Ann Mtg Digestive Disease Week 1999 May. View abstract. View abstract. The roots are commonly used in Traditional Chinese Medicine (TCM) for many purposes. Pseudohyperaldosteronism, liquorice, and hypertension. A., Braun, T. M., and Jacobson, J. J. View abstract. [Study on activating blood and eliminating stasis of total paeony glycoside(TPG)]. Teelucksingh S, Mackie AD, Burt D, McIntyre MA, Brett L, Edwards CR. Arch Pharm Res 2002;25(3):293-299. Allergic contact dermatitis to Glycyrrhiza inflata root extract in an anti-acne cosmetic product. An unusual cause of hypokalemic paralysis: chronic licorice ingestion. View abstract. Evid Based Complement Alternat Med. View abstract. Shintani, S., Murase, H., Tsukagoshi, H., and Shiigai, T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Licorice, tobacco chewing, and hypertension. 2005 - 2023 WebMD LLC. Zhong Xi Yi Jie He Za Zhi 1986;6:714-6, 707. . Clin Rheumatol. Hasani-Ranjbar, S., Nayebi, N., Moradi, L., Mehri, A., Larijani, B., and Abdollahi, M. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review. The benefits of licorice root can be enjoyed as a tea, supplement, tincture, or topical treatment, and even as candies. The effect of a traditional Chinese prescription for a case of lung carcinoma. View abstract. View abstract. Part 182 -- Substances Generally Recognized As Safe. Goto, F., Asama, Y., and Ogawa, K. Sho-saiko-to-ka-kikyo-sekko as an alternative treatment for chronic tonsillitis to avoid surgery. Information from this source is evidence-based and objective, and without commercial influence. Indian J Med Res 1993;98:69-74. View abstract. J Endocrinol Invest 1996;19:624-9. View abstract. View abstract. 17. View abstract. Ito A, Hayashi N, Katayama K, and et al. View abstract. Effects of Paeoniae Radix, a traditional Chinese medicine, on the pharmacokinetics of phenytoin. It contains kojic acid, witch hazel, and licorice extracts that reduce melanin production and exfoliate . J Clin Psychopharmacol 1997;17(3):234-235. J Clin Anesth 2019;54:25-32. J Pharm Pharmacol 2003;55:1275-82. [Effectiveness of interferon, glycyrrhizin combination therapy in patients with chronic hepatitis C]. J Am Acad Dermatol 2011;65(4):699-714. View abstract. 2000;19(8):434-439. View abstract. Ann Noninvasive Electrocardiol. This week, The New England Journal of Medicine reported that a man with a poor diet died of cardiac arrest after eating a bag-and-a-half of black licorice daily for weeks. October 15, 2021. Medically reviewed by Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT By Kirsten Nunez on October 16, 2020. J Pharmacobiodyn 1983;6:153-60. . Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses. 1. View abstract. View abstract. Corse, F. M., Galgani, S., Gasparini, C., Giacanelli, M., and Piazza, G. Acute hypokalemic myopathy due to chronic licorice ingestion: report of a case. Acute myopathy associated with chronic licorice ingestion: reversible loss of myoadenylate deaminase activity. View abstract. Phytomedicine 2003;10:271-85. View abstract. Lin, J. C. Mechanism of action of glycyrrhizic acid in inhibition of Epstein-Barr virus replication in vitro. Neth J Med 2005;63:119-20. All rights reserved. View abstract. Lancet 2-10-1979;1(8111):319. Shen, A. Y., Wang, T. S., Huang, M. H., Liao, C. H., Chen, S. J., and Lin, C. C. Antioxidant and antiplatelet effects of dang-gui-shao-yao-san on human blood cells.